Compound 48/80

Compound 48/80
Names
	IUPAC name Poly({2-methoxy-5-[2-(methylamino)ethyl]-1,3-phenylene}methylene)
Identifiers
RTECS number	Gk2402500;
UN number	2811
Properties
Chemical formula	(C11H15NO)n
Molar mass	Variable
Solubility in water	50 mg/mL
Hazards
	GHS labelling:
Hazard statements	H301, H311, H331
Precautionary statements	P233, P261, P280, P301, P302, P304, P310, P312, P330, P340, P352, P403
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Compound 48/80 is a polymer produced by the condensation of N-methyl-p-methoxyphenethylamine with formaldehyde.^[1] It promotes histamine release,^[2] and in biochemical research, compound 48/80 is used to promote mast cell degranulation.^[3]

References

^ ^a ^b "Compound48/80". Sigma-Aldrich.
^ A. M. Rothschild (1970). "Mechanisms of histamine release by compound 48/80". Br J Pharmacol. 38 (1): 253–262. doi:10.1111/j.1476-5381.1970.tb10354.x. PMC 1702640. PMID 4189829.
^ Schemann, Michael; Kugler, Eva Maria; Buhner, Sabine; Eastwood, Christopher; Donovan, Jemma; Jiang, Wen; Grundy, David (2012). "The Mast Cell Degranulator Compound 48/80 Directly Activates Neurons". PLOS ONE. 7 (12): e52104. Bibcode:2012PLoSO...752104S. doi:10.1371/journal.pone.0052104. PMC 3525567. PMID 23272218.{{cite journal}}: CS1 maint: article number as page number (link)

[SA-1] "Compound48/80". Sigma-Aldrich.

[2] A. M. Rothschild (1970). "Mechanisms of histamine release by compound 48/80". Br J Pharmacol. 38 (1): 253–262. doi:10.1111/j.1476-5381.1970.tb10354.x. PMC 1702640. PMID 4189829.

[3] Schemann, Michael; Kugler, Eva Maria; Buhner, Sabine; Eastwood, Christopher; Donovan, Jemma; Jiang, Wen; Grundy, David (2012). "The Mast Cell Degranulator Compound 48/80 Directly Activates Neurons". PLOS ONE. 7 (12): e52104. Bibcode:2012PLoSO...752104S. doi:10.1371/journal.pone.0052104. PMC 3525567. PMID 23272218.{{cite journal}}: CS1 maint: article number as page number (link)

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