The D1-like receptors are a subfamily of dopamine receptors that bind the endogenous neurotransmitter dopamine.[1] The D1-like subfamily consists of two G protein–coupled receptors that are coupled to Gs and mediate excitatory neurotransmission, of which include D1 and D5.[2] For more information, please see the respective main articles of the individual subtypes:
See also
References
- ^ "Dopamine D1-Like Receptor Family Signaling Pathways". Rndsystems. 26 March 2022. Retrieved 26 March 2022.
- ^ Sun, Bingfa; Feng, Dan; Chu, Matthew Ling-Hon; Fish, Inbar; Lovera, Silvia; Sands, Zara A.; Kelm, Sebastian; Valade, Anne; Wood, Martyn; Ceska, Tom; Kobilka, Tong Sun (2021-06-03). "Crystal structure of dopamine D1 receptor in complex with G protein and a non-catechol agonist". Nature Communications. 12 (1): 3305. Bibcode:2021NatCo..12.3305S. doi:10.1038/s41467-021-23519-9. ISSN 2041-1723. PMC 8175458. PMID 34083522.
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Signaling pathways | |
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Agents | |
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By distance | |
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Other concepts | |
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| Agonists |
- Benzazepines: 6-Br-APB
- Fenoldopam
- SKF-38,393
- SKF-77,434
- SKF-81,297
- SKF-82,958
- SKF-83,959
- Trepipam
- Zelandopam
- Ergolines: Cabergoline
- CY-208,243
- Dihydroergocryptine
- LEK-8829
- Lisuride
- Pergolide
- Terguride
- Dihydrexidine derivatives: A-77636
- A-86929
- Adrogolide (ABT-431, DAS-431)
- Dihydrexidine
- Dinapsoline
- Dinoxyline
- Doxanthrine
- Phenethylamines: BCO-001
- Deoxyepinephrine (N-methyldopamine, epinine)
- Dopexamine
- Etilevodopa
- Ibopamine
- L-DOPA (levodopa)
- Melevodopa
- L-Phenylalanine
- L-Tyrosine
- XP21279
- Others: A-68930
- Apomorphine
- Isocorypalmine
- Nuciferine
- PF-6649751
- PF 6669571
- Propylnorapomorphine
- Rotigotine
- SKF-89,145
- SKF-89,626
- Stepholidine
- Tavapadon
- Tetrahydropalmatine
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PAMs |
- Tetrahydroisoquinolines: DETQ
- DPTQ
- Mevidalen
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Antagonists |
- Typical antipsychotics: Butaclamol
- Chlorpromazine
- Chlorprothixene
- Flupentixol (flupenthixol) (+melitracen)
- Fluphenazine
- Loxapine
- Perphenazine (+amitriptyline)
- Pifluthixol
- Thioridazine
- Thiothixene
- Trifluoperazine (+tranylcypromine)
- Zuclopenthixol
- Atypical antipsychotics: Asenapine
- Clorotepine
- Clotiapine
- Clozapine
- DHA-clozapine
- Fluperlapine
- Iloperidone
- Norclozapine
- Norquetiapine
- Olanzapine (+fluoxetine)
- Paliperidone
- Quetiapine
- Risperidone
- Tefludazine
- Zicronapine
- Ziprasidone
- Zotepine
- Others: Berupipam
- Ecopipam
- EEDQ
- Metitepine (methiothepin)
- Odapipam
- Perlapine
- SCH-23390
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D2-like | Agonists |
- Adamantanes: Amantadine
- Memantine
- Rimantadine
- Aminotetralins: 5-OH-DPAT
- 7-OH-DPAT
- 8-OH-PBZI
- CHF-1024
- Nolomirole
- Rotigotine
- UH-232
- Ergolines: Bromocriptine
- Cabergoline
- Chanoclavine
- Dihydroergocryptine
- Disulergine
- Dosergoside
- Epicriptine
- Ergocornine
- Etisulergine
- Lergotrile
- Lisuride
- LSD
- Mesulergine
- Metergoline
- Pergolide
- Proterguride
- Terguride
- Dihydrexidine derivatives: 2-OH-NPA
- Ciladopa
- Dihydrexidine
- Dinoxyline
- N,N-Propyldihydrexidine
- Phenethylamines: Deoxyepinephrine (N-methyldopamine, epinine)
- Dopexamine
- Etilevodopa
- Ibopamine
- L-DOPA (levodopa)
- L-Phenylalanine
- L-Tyrosine
- Melevodopa
- XP21279
- Atypical antipsychotics: Alentemol (U-66444B)
- Aripiprazole (+sertraline)
- Aripiprazole lauroxil
- Bifeprunox
- Brexpiprazole
- Brilaroxazine
- Cariprazine
- F-15063
- Lumateperone
- Norclozapine
- Others: 3-PPP
- A-412997
- ABT-670
- ABT-724
- Adrafinil
- Aplindore
- Apomorphine
- Arketamine
- Armodafinil
- BP-897
- Captodiame
- CP-226,269
- Dizocilpine
- Esketamine
- Flibanserin
- Ketamine
- Modafinil
- Naxagolide
- OSU-6162
- Pardoprunox
- PD-128,907
- PD-168,077
- PF-219,061
- PF-592,379
- Phencyclidine
- Piribedil
- Pramipexole
- Preclamol
- Propylnorapomorphine
- Pukateine
- Quinagolide
- Quinelorane
- Quinpirole
- RDS-127
- Ro10-5824
- Ropinirole
- Roxindole
- Salvinorin A
- SKF-83,959
- Sumanirole
- Talipexole
- Umespirone
- WAY-100,635
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Antagonists | |
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- See also: Receptor/signaling modulators
- Adrenergics
- Serotonergics
- Monoamine reuptake inhibitors
- Monoamine releasing agents
- Monoamine metabolism modulators
- Monoamine neurotoxins
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