FAM114A2

FAM114A2
Identifiers
Aliases	FAM114A2, 133K02, C5orf3, family with sequence similarity 114 member A2
External IDs	MGI: 1917629; HomoloGene: 10270; GeneCards: FAM114A2; OMA:FAM114A2 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	154,038,936 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	57,409,443 bp
RNA expression pattern
	Top expressed in
	epithelium of colon; ; Achilles tendon; ; secondary oocyte; ; sperm; ; testicle; ; Epithelium of choroid plexus; ; islet of Langerhans; ; body of pancreas; ; left testis; ; right testis;
	Top expressed in
	seminal vesicula; ; condyle; ; Rostral migratory stream; ; muscle of thigh; ; granulocyte; ; neural layer of retina; ; ganglionic eminence; ; saccule; ; lacrimal gland; ; vestibular sensory epithelium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	purine nucleotide binding;
Cellular component	cellular component;
Biological process	biological process;
	Sources:Amigo / QuickGO
Orthologs
	10827
	67726
	ENSG00000055147
	ENSMUSG00000020523
	Q9NRY5
	Q8VE88
	NM_018691; NM_001317993; NM_001317994; NM_001317995
	NM_001168667; NM_001168668; NM_026342
	NP_001304922; NP_001304923; NP_001304924; NP_061161
	NP_001162138; NP_001162139; NP_080618
	Wikidata
View/Edit Human	View/Edit Mouse

FAM114A2 (chromosome 5 open reading frame 3) is a gene on chromosome 5 in humans that encodes a protein FAM114A2. The protein function is not well known. FAM114A2 is, however, highly conserved in mammals with homologs both in fungi and plants.

Species	Accession #	Identity
macaca mulatta	XM_001102467	78.1%
Pan troglodytes	XM_518045	89.7%
bos taurus	NP_001033166	85.6%
Pongo abelii	XM_002816109	87.8%
Mus musculus	NM_026342.3	79%
Callithrix jacchus	XP_002744467	94.7%

Protein

The FAM114A2 protein is 505 amino acids long^[5] with a molecular weight of 55.5 kdal and an isoelectric point of 4.66.^[6] It is predicted to stay in the nucleus after translation ^[7] There is evidence that c5orf3 interacts with another protein of unknown function from chromosome 5, c5orf4 ^[8] This protein is thought to include a P loop^[9] that suggests a role in ATP- and/or GTP-binding ^[10]

Gene

The FAM114A2 gene is located on chromosome 5 (5q31-33).^[11] This gene has 14 exons spanning through its sequence.^[5] The coding sequence is 2886 base pairs with a 5’ UTR of 94 base pairs and a 3’ UTR of 1273 base pairs.^[5] It is expressed at high levels in most tissues of the human body.^[11] It is also highly expressed in tissues in the human brain ^[12]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000055147 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020523 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b ^c Homo sapiens family with sequence similarity 114, member A2 (FAM114A2) - Nucleotide - NCBI
^ Biology workbench: http://seqtool.sdsc.edu/CGI/BW.cgi#!
^ PSORT WWW Server
^ STRING: http://string-db.org/newstring_cgi/show_network_section.pl Archived 2013-05-15 at the Wayback Machine.
^ "STRING: Functional protein association networks". Archived from the original on 2021-10-26. Retrieved 2011-05-07.
^ Saraste M, Sibbald PR, Wittinghofer A (November 1990). "The P-loop--a common motif in ATP- and GTP-binding proteins". Trends Biochem. Sci. 15 (11): 430–4. doi:10.1016/0968-0004(90)90281-f. PMID 2126155.
^ ^a ^b FAM114A2 Gene - GeneCards | F1142 Protein | F1142 Antibody
^ Allen Brain Atlas: http://human.brain-map.org/search?type=mi Archived 2011-08-18 at the Wayback Machine

External links

Human FAM114A2 genome location and FAM114A2 gene details page in the UCSC Genome Browser.

Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000055147 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020523 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[ncbi-5] Homo sapiens family with sequence similarity 114, member A2 (FAM114A2) - Nucleotide - NCBI

[6] Biology workbench: http://seqtool.sdsc.edu/CGI/BW.cgi#!

[7] PSORT WWW Server

[8] STRING: http://string-db.org/newstring_cgi/show_network_section.pl Archived 2013-05-15 at the Wayback Machine.

[9] "STRING: Functional protein association networks". Archived from the original on 2021-10-26. Retrieved 2011-05-07.

[10] Saraste M, Sibbald PR, Wittinghofer A (November 1990). "The P-loop--a common motif in ATP- and GTP-binding proteins". Trends Biochem. Sci. 15 (11): 430–4. doi:10.1016/0968-0004(90)90281-f. PMID 2126155.

[www.genecards.org-11] FAM114A2 Gene - GeneCards | F1142 Protein | F1142 Antibody

[12] Allen Brain Atlas: http://human.brain-map.org/search?type=mi Archived 2011-08-18 at the Wayback Machine

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Protein

Gene

References

External links

Further reading