Interleukin-1 receptor

interleukin 1 receptor, type II
interleukin 1 receptor, type II
Identifiers
Symbol	IL1R2
Alt. symbols	IL1RB
NCBI gene	7850
HGNC	5994
OMIM	147811
RefSeq	NM_173343
UniProt	P27930
Other data
Locus	Chr. 2 q12
Structures
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Structures	Swiss-model
Domains	InterPro

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Structures	Swiss-model
Domains	InterPro

interleukin 1 receptor, type I
interleukin 1 receptor, type I
Identifiers
Symbol	IL1R1
Alt. symbols	IL1R, IL1RA
NCBI gene	3554
HGNC	5993
OMIM	147810
RefSeq	NM_000877
UniProt	P14778
Other data
Locus	Chr. 2 q12
Structures
Search for
Structures	Swiss-model
Domains	InterPro

interleukin 1 receptor accessory protein

Identifiers

Symbol

IL1RAP

Alt. symbols

IL-1RAcP, IL1R3, C3orf13

Other data

Chr. 3 q28

Search for
Structures	Swiss-model
Domains	InterPro

Interleukin-1 receptor (IL-1R) is a cytokine receptor which binds interleukin 1.^[1] Two forms of the receptor exist. The type I receptor is primarily responsible for transmitting the inflammatory effects of interleukin-1 (IL-1) while type II receptors may act as a suppressor of IL-1 activity by competing for IL-1 binding.^[1] Also opposing the effects of IL-1 is the IL-1 receptor antagonist (IL-1RA).^[2]

The IL-1 receptor accessory protein (IL1RAP) is a transmembrane protein that interacts with IL-1R and is required for IL-1 signal transduction.^[3]

References

^ ^a ^b Kuno K, Matsushima K (1994). "The IL-1 receptor signaling pathway". J. Leukoc. Biol. 56 (5): 542–7. doi:10.1002/jlb.56.5.542. PMID 7964161. S2CID 43095473. Archived from the original (abstract page) on 2005-05-07. Retrieved 2008-02-28.
^ Arend WP (1991). "Interleukin 1 receptor antagonist. A new member of the interleukin 1 family". J. Clin. Invest. 88 (5): 1445–51. doi:10.1172/JCI115453. PMC 295645. PMID 1834696.
^ Wesche H, Korherr C, Kracht M, Falk W, Resch K, Martin MU (March 1997). "The interleukin-1 receptor accessory protein (IL-1RAcP) is essential for IL-1-induced activation of interleukin-1 receptor-associated kinase (IRAK) and stress-activated protein kinases (SAP kinases)". J. Biol. Chem. 272 (12): 7727–31. doi:10.1074/jbc.272.12.7727. PMID 9065432.

External links

Receptors,+Interleukin-1 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

[pmid7964161-1] Kuno K, Matsushima K (1994). "The IL-1 receptor signaling pathway". J. Leukoc. Biol. 56 (5): 542–7. doi:10.1002/jlb.56.5.542. PMID 7964161. S2CID 43095473. Archived from the original (abstract page) on 2005-05-07. Retrieved 2008-02-28.

[pmid1834696-2] Arend WP (1991). "Interleukin 1 receptor antagonist. A new member of the interleukin 1 family". J. Clin. Invest. 88 (5): 1445–51. doi:10.1172/JCI115453. PMC 295645. PMID 1834696.

[pmid9065432-3] Wesche H, Korherr C, Kracht M, Falk W, Resch K, Martin MU (March 1997). "The interleukin-1 receptor accessory protein (IL-1RAcP) is essential for IL-1-induced activation of interleukin-1 receptor-associated kinase (IRAK) and stress-activated protein kinases (SAP kinases)". J. Biol. Chem. 272 (12): 7727–31. doi:10.1074/jbc.272.12.7727. PMID 9065432.

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